Association of α-klotho levels with serum copper and cadmium levels in schizophrenia

Introduction Schizophrenia is associated with harmful health effects such as oxidative stress from heavy metal exposure. We considered the relationship between genes and metals in association then investigated serum α- klotho copper cadmium exposure among schizophrenia patients western India. Objectives To Methods 100 individuals participated out of which 50 were diagnosed schizophrenia, severity was assessed by using PANSS score taken controls General questionnaire. Serum Klotho levels estimated ELISA. Cadmium (Cd) Copper (Cu) Atomic Absorption Spectrophotometry. Results The mean ± SD Cd, Cu 1.05 0.55 μg/dl, 135.5 51.25 μg/ml 62.9 35.1 ng/ml respectively 0.23 0.17 147.9 25.42 78.6 34.6 controls. differences study group highly significant (p <0.05). Conclusions Both Cd significantly raised schizophrenic compared showed a statistically decreasing trend increasing levels. These results suggest that may be decreased cognition schizophrenia. Disclosure Interest None Declared